Ontology highlight
ABSTRACT:
SUBMITTER: Takala H
PROVIDER: S-EPMC3327698 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120416 4
The Rap1-GTP interacting adapter protein (RIAM) is an important protein in Rap1-mediated integrin activation. By binding to both Rap1 GTPase and talin, RIAM recruits talin to the cell membrane, thus facilitating talin-dependent integrin activation. In this article, we studied the role of the RIAM Ras-association (RA) and pleckstrin-homology (PH) domains in the interaction with Rap1. We found that the RA domain was sufficient for GTP-dependent interaction with Rap1B, and the addition of the PH do ...[more]