Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5386551 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cell death & disease 20170316 3
Loss or dysfunction of tumor suppressor retinoblastoma (RB) is a common feature in various tumors, and contributes to cancer cell stemness and drug resistance to cancer therapy. However, the strategy to suppress or eliminate Rb-deficient tumor cells remains unclear. In the present study, we accidentally found that reduction of DNA replication licensing factor MCM7 induced more apoptosis in RB-deficient tumor cells than in control tumor cells. Moreover, after a drug screening and further studies, ...[more]