Ontology highlight
ABSTRACT:
SUBMITTER: Safina A
PROVIDER: S-EPMC5389579 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Safina Alfiya A Cheney Peter P Pal Mahadeb M Brodsky Leonid L Ivanov Alexander A Kirsanov Kirill K Lesovaya Ekaterina E Naberezhnov Denis D Nesher Elimelech E Koman Igor I Wang Dan D Wang Jianming J Yakubovskaya Marianna M Winkler Duane D Gurova Katerina K
Nucleic acids research 20170201 4
Transitions of B-DNA to alternative DNA structures (ADS) can be triggered by negative torsional strain, which occurs during replication and transcription, and may lead to genomic instability. However, how ADS are recognized in cells is unclear. We found that the binding of candidate anticancer drug, curaxin, to cellular DNA results in uncoiling of nucleosomal DNA, accumulation of negative supercoiling and conversion of multiple regions of genomic DNA into left-handed Z-form. Histone chaperone FA ...[more]