Ontology highlight
ABSTRACT:
SUBMITTER: McClurg UL
PROVIDER: S-EPMC5389688 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
McClurg Urszula L UL Cork David M W DMW Darby Steven S Ryan-Munden Claudia A CA Nakjang Sirintra S Mendes Côrtes Leticia L Treumann Achim A Gaughan Luke L Robson Craig N CN
Nucleic acids research 20170201 4
The androgen receptor (AR) is the main driver of prostate cancer (PC) development and progression, and the primary therapeutic target in PC. To date, two functional ubiquitination sites have been identified on AR, both located in its C-terminal ligand binding domain (LBD). Recent reports highlight the emergence of AR splice variants lacking the LBD that can arise during disease progression and contribute to castrate resistance. Here, we report a novel N-terminal ubiquitination site at lysine 311 ...[more]