Ontology highlight
ABSTRACT:
SUBMITTER: Menon D
PROVIDER: S-EPMC5391759 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20170221 15
mTOR, the mammalian target of rapamycin, integrates growth factor and nutrient signals to promote a transformation from catabolic to anabolic metabolism, cell growth, and cell cycle progression. Phosphatidic acid (PA) interacts with the FK506-binding protein-12-rapamycin-binding (FRB) domain of mTOR, which stabilizes both mTOR complexes: mTORC1 and mTORC2. We report here that mTORC1 and mTORC2 are activated in response to exogenously supplied fatty acids via the <i>de novo</i> synthesis of PA, a ...[more]