Ontology highlight
ABSTRACT:
SUBMITTER: Walline HM
PROVIDER: S-EPMC5392184 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Walline Heather M HM Goudsmit Christine M CM McHugh Jonathan B JB Tang Alice L AL Owen John H JH Teh Bin T BT McKean Erin E Glover Thomas W TW Graham Martin P MP Prince Mark E ME Chepeha Douglas B DB Chinn Steven B SB Ferris Robert L RL Gollin Susanne M SM Hoffmann Thomas K TK Bier Henning H Brakenhoff Ruud R Bradford Carol R CR Carey Thomas E TE
Head & neck 20170225 5
<h4>Background</h4>Human papillomavirus (HPV)-positive oropharyngeal cancer is generally associated with excellent response to therapy, but some HPV-positive tumors progress despite aggressive therapy. The purpose of this study was to evaluate viral oncogene expression and viral integration sites in HPV16- and HPV18-positive squamous cell carcinoma lines.<h4>Methods</h4>E6/E7 alternate transcripts were assessed by reverse transcriptase-polymerase chain reaction (RT-PCR). Detection of integrated ...[more]