MTOR Signaling in Growth, Metabolism, and Disease.
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ABSTRACT:
SUBMITTER: Saxton RA
PROVIDER: S-EPMC5394987 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
mTOR Signaling in Growth, Metabolism, and Disease.
Saxton Robert A RA Sabatini David M DM
Cell 20170301 6
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process. Here, we review recent advances in our understanding ...[more]
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