Predictive markers for early conversion of iRBD to neurodegenerative synucleinopathy diseases.

ABSTRACT:

Objective

To determine the predictive value of clinical assessment and dopamine transporter (DAT) uptake for the early development of neurodegenerative synucleinopathy diseases from idiopathic REM sleep behavior disorder (iRBD) over 5 years in a Chinese population.

Methods

Forty-three patients with iRBD were administered clinical assessment tests, and 35 were examined by DAT-SPECT imaging during 2011. Cox proportional hazard and Kaplan-Meier analyses were used to evaluate the predictive value of the markers in a follow-up study over 5 years.

Results

Eighteen patients (41.9%) developed neurodegenerative synucleinopathy diseases after a median of 4.1 years of prospective follow-up (median interval of 10.5 years from the estimated onset of iRBD symptoms). Patients with h

SUBMITTER: Li Y 

PROVIDER: S-EPMC5395071 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature