Unknown

Dataset Information

0

Traceless Rhodium-Catalyzed Hydroacylation Using Alkyl Aldehydes: The Enantioselective Synthesis of ?-Aryl Ketones.


ABSTRACT: A one-pot three-step sequence involving Rh-catalyzed alkene hydroacylation, sulfide elimination and Rh-catalyzed aryl boronic acid conjugate addition gave products of traceless chelation-controlled hydroacylation employing alkyl aldehydes. The stereodefined ?-aryl ketones were obtained in good yields with excellent control of enantioselectivity. Good variation of all three reaction components is possible.

SUBMITTER: Bouisseau A 

PROVIDER: S-EPMC5396316 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Traceless Rhodium-Catalyzed Hydroacylation Using Alkyl Aldehydes: The Enantioselective Synthesis of β-Aryl Ketones.

Bouisseau Anaïs A   Gao Ming M   Willis Michael C MC  

Chemistry (Weinheim an der Bergstrasse, Germany) 20160926 44


A one-pot three-step sequence involving Rh-catalyzed alkene hydroacylation, sulfide elimination and Rh-catalyzed aryl boronic acid conjugate addition gave products of traceless chelation-controlled hydroacylation employing alkyl aldehydes. The stereodefined β-aryl ketones were obtained in good yields with excellent control of enantioselectivity. Good variation of all three reaction components is possible. ...[more]

Similar Datasets

| S-EPMC4140243 | biostudies-literature
| S-EPMC10108320 | biostudies-literature
| S-EPMC4091274 | biostudies-literature
| S-EPMC4847752 | biostudies-literature
| S-EPMC3248813 | biostudies-literature
| S-EPMC5810545 | biostudies-literature
| S-EPMC6251884 | biostudies-other
| S-EPMC3365512 | biostudies-literature
| S-EPMC2887700 | biostudies-literature
| S-EPMC5238525 | biostudies-other