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Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols.

ABSTRACT: In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o-benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o-Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio-carboxylation of resveratrol on a preparative scale with 95% yield.

SUBMITTER: Plasch K 

PROVIDER: S-EPMC5396361 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols.

Plasch Katharina K   Resch Verena V   Hitce Julien J   Popłoński Jarosław J   Faber Kurt K   Glueck Silvia M SM  

Advanced synthesis & catalysis 20170118 6

In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of <i>o</i>-benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. <i>o</i>-Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio-carboxylation of  ...[more]

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