Ontology highlight
ABSTRACT:
SUBMITTER: Cabral M
PROVIDER: S-EPMC5396545 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cabral Marleny M Cheng Xin X Singh Sukhwinder S Ivessa Andreas S AS
Cell reports 20161101 7
There is substantial evidence that genomic instability increases during aging. Replication pausing (and stalling) at difficult-to-replicate chromosomal sites may induce genomic instability. Interestingly, in aging yeast cells, we observed reduced replication pausing at various natural replication pause sites (RPSs) in ribosomal DNA (rDNA) and non-rDNA locations (e.g., silent replication origins and tRNA genes). The reduced pausing occurs independent of the DNA helicase Rrm3p, which facilitates r ...[more]