Ontology highlight
ABSTRACT:
SUBMITTER: Song JM
PROVIDER: S-EPMC5432308 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Song Jung Min JM Molla Kalkidan K Anandharaj Arunkumar A Cornax Ingrid I O Sullivan M Gerard MG Kirtane Ameya R AR Panyam Jayanth J Kassie Fekadu F
Oncotarget 20170401 16
Higher levels of hyaluronan (HA) and its receptors CD44 and RHAMM have been associated with poor prognosis and metastasis in NSCLC. In the current study, our goal was to define, using cellular and orthotopic lung tumor models, the role of HA-CD44/RHAMM signaling in lung carcinogenesis and to assess the potential of triptolide to block HA-CD44/RHAMM signaling and thereby suppress the development and progression of lung cancer. Triptolide reduced the viability of five non-small cell lung cancer (N ...[more]