Ontology highlight
ABSTRACT:
SUBMITTER: Islam M
PROVIDER: S-EPMC5398307 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Islam Maidul M Shinde Ganesh P GP Hotha Srinivas S
Chemical science 20161115 3
The global incidence of tuberculosis is increasing at an alarming rate, and <i>Mycobacterium tuberculosis</i> (Mtb) is the causative agent for tuberculosis, a disease with high mortality. Lipoarabinomannan (LAM) is one of the major components of the Mtb cellular envelope and is an attractive scaffold for developing anti-tubercular drugs, vaccines and diagnostics. Herein, a highly convergent strategy is developed to synthesize heneicosasaccharyl arabinomannan for the first time. The arabinomannan ...[more]