Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC5400543 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Zhang Jun J Wang Xue-Jiao XJ Liu Xin X Huan Yi Y Yang Miao-Miao MM Shen Zhu-Fang ZF Jia Wen-Qing WQ Jing Zhi Z Wang Shu-Qing SQ Xu Wei-Ren WR Cheng Xian-Chao XC Wang Run-Ling RL
Oncotarget 20170301 13
Peroxisome proliferators-activated receptors (PPARα, γ and δ) are potentially effective targets for Type 2 diabetes mellitus therapy. The severe effects of known glitazones and the successfully approved agents (saroglitazar and lobeglitazone) motivated us to study novelly potent PPARs drugs with improved safety profile. In this work, we received 15 carboxylic acids based on the combination principle to integrate the polar head of bezafibrate with the hydrophobic tail of pioglitazone. Another 12 ...[more]