Ontology highlight
ABSTRACT:
SUBMITTER: Chuang JC
PROVIDER: S-EPMC5402884 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Chuang Jody C JC Stehr Henning H Liang Ying Y Das Millie M Huang Jane J Diehn Maximilian M Wakelee Heather A HA Neal Joel W JW
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20170204 5
<h4>Introduction</h4>Erb-b2 receptor tyrosine kinase 2 gene (ERBB2) (also called HER2) has long been recognized as an oncogenic driver in some breast and gastroesophageal cancers in which amplification of this gene confers sensitivity to treatment with Erb-b2 receptor tyrosine kinase 2 (ERBB2)-directed agents. More recently, somatic mutations in ERBB2 have been reported in 1% to 2% of patients with lung adenocarcinoma. Previous case series have suggested clinical tumor responses using anti-ERBB2 ...[more]