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ABSTRACT: Objective
To determine whether metabolic responses to short-term overfeeding predict longitudinal changes in body weight.Methods
Twenty-four-hour energy expenditure (EE) and substrate utilization were measured at baseline in a room calorimeter following 3 days of eucaloric and hypercaloric feeding (40% excess) in a sample of lean adults (n: 34; age: 28?±?2 y; BMI: 22?±?3 kg/m2 ). Body mass and fat mass (dual-energy x-ray absorptiometry) were measured annually for 5 years. Regression analyses examined whether changes in EE and fuel use with overfeeding predicted body weight and composition changes over 5 years.Results
Overfeeding increased EE and reduced fat oxidation when examined over the 24-hour, waking, and nocturnal periods. Absolute change in body mass over 5 years was 3.0?±?0.6 kg (average rate of change?=?0.7?±?0.1 kg/y, P?ConclusionsFailure to maintain fat oxidation at night following a period of overfeeding appears to be associated with a metabolic phenotype favoring weight gain.
SUBMITTER: Rynders CA
PROVIDER: S-EPMC5407418 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Rynders Corey A CA Bergouignan Audrey A Kealey Elizabeth E Bessesen Daniel H DH
Obesity (Silver Spring, Md.) 20170501 5
<h4>Objective</h4>To determine whether metabolic responses to short-term overfeeding predict longitudinal changes in body weight.<h4>Methods</h4>Twenty-four-hour energy expenditure (EE) and substrate utilization were measured at baseline in a room calorimeter following 3 days of eucaloric and hypercaloric feeding (40% excess) in a sample of lean adults (n: 34; age: 28 ± 2 y; BMI: 22 ± 3 kg/m<sup>2</sup> ). Body mass and fat mass (dual-energy x-ray absorptiometry) were measured annually for 5 yea ...[more]