Ontology highlight
ABSTRACT:
SUBMITTER: Reverchon F
PROVIDER: S-EPMC5407765 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Reverchon Flora F Mortaud Stéphane S Sivoyon Maëliss M Maillet Isabelle I Laugeray Anthony A Palomo Jennifer J Montécot Céline C Herzine Améziane A Meme Sandra S Meme William W Erard François F Ryffel Bernhard B Menuet Arnaud A Quesniaux Valérie F J VFJ
PLoS pathogens 20170427 4
Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors. The murine model of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA)-infection reproduces several of these features. We reported recently increased levels of IL-33 protein in brain undergoing ECM and the involvement of IL-33/ST2 pathway in ECM development. Here we show that PbA-infection induced early short term and spatial memory defects, prior to bloo ...[more]