Ontology highlight
ABSTRACT:
SUBMITTER: Pearce NM
PROVIDER: S-EPMC5413968 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Pearce Nicholas M NM Krojer Tobias T Bradley Anthony R AR Collins Patrick P Nowak Radosław P RP Talon Romain R Marsden Brian D BD Kelm Sebastian S Shi Jiye J Deane Charlotte M CM von Delft Frank F
Nature communications 20170424
In macromolecular crystallography, the rigorous detection of changed states (for example, ligand binding) is difficult unless signal is strong. Ambiguous ('weak' or 'noisy') density is experimentally common, since molecular states are generally only fractionally present in the crystal. Existing methodologies focus on generating maximally accurate maps whereby minor states become discernible; in practice, such map interpretation is disappointingly subjective, time-consuming and methodologically u ...[more]