Ontology highlight
ABSTRACT:
SUBMITTER: Aryal P
PROVIDER: S-EPMC5415359 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Aryal Prafulla P Jarerattanachat Viwan V Clausen Michael V MV Schewe Marcus M McClenaghan Conor C Argent Liam L Conrad Linus J LJ Dong Yin Y YY Pike Ashley C W ACW Carpenter Elisabeth P EP Baukrowitz Thomas T Sansom Mark S P MSP Tucker Stephen J SJ
Structure (London, England : 1993) 20170406 5
The mechanosensitive two-pore domain (K2P) K<sup>+</sup> channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in a lipid bilayer. We show that TREK-2 moves from the "down" to "up" conformation in direct response to membrane stretch, and examine the role of the transmembrane pressure profile in this pro ...[more]