Ontology highlight
ABSTRACT:
SUBMITTER: Nematian-Ardestani E
PROVIDER: S-EPMC5626358 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Nematian-Ardestani Ehsan E Jarerattanachat Viwan V Aryal Prafulla P Sansom Mark S P MSP Tucker Stephen J SJ
Channels (Austin, Tex.) 20170719 5
The TREK-2 (KCNK10) K2P potassium channel can be regulated by variety of polymodal stimuli including pressure. In a recent study, we demonstrated that this mechanosensitive K<sup>+</sup> channel responds to changes in membrane tension by undergoing a major structural change from its 'down' state to the more expanded 'up' state conformation. These changes are mostly restricted to the lower part of the protein within the bilayer, but are allosterically coupled to the primary gating mechanism locat ...[more]