Unknown

Dataset Information

0

Catalytic Upgrading in Bacteria-Compatible Conditions via a Biocompatible Aldol Condensation.


ABSTRACT: Integrating non-enzymatic chemistry with living systems has the potential to greatly expand the types and yields of chemicals that can be sourced from renewable feedstocks. The in situ conversion of microbial metabolites to higher order products will ensure their continuous generation starting from a given cellular reaction mixture. We present here a systematic study of different organocatalysts that enable aldol condensation in biological media under physiological conditions of neutral pH, moderate temperature, and ambient pressure. The relative toxicities of each catalyst were tested against bacteria, and the catalysts were found to provide good yields of homoaldol products in bacterial cultures containing aldehydes. Lastly, we demonstrate that a biocompatible oil can be used to selectively extract the upgraded products, which enabes facile isolation and decreases the product toxicity to microbes.

SUBMITTER: Domaille DW 

PROVIDER: S-EPMC5417690 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Catalytic Upgrading in Bacteria-Compatible Conditions via a Biocompatible Aldol Condensation.

Domaille Dylan W DW   Hafenstine Glenn R GR   Greer Mattias A MA   Goodwin Andrew P AP   Cha Jennifer N JN  

ACS sustainable chemistry & engineering 20160215 3


Integrating non-enzymatic chemistry with living systems has the potential to greatly expand the types and yields of chemicals that can be sourced from renewable feedstocks. The in situ conversion of microbial metabolites to higher order products will ensure their continuous generation starting from a given cellular reaction mixture. We present here a systematic study of different organocatalysts that enable aldol condensation in biological media under physiological conditions of neutral pH, mode  ...[more]

Similar Datasets

| S-EPMC6826340 | biostudies-literature
| S-EPMC10420871 | biostudies-literature
| S-EPMC10798669 | biostudies-literature
| S-EPMC4168897 | biostudies-literature
| S-EPMC6851556 | biostudies-literature
| S-EPMC10017038 | biostudies-literature
| S-EPMC4760845 | biostudies-literature
| S-EPMC2516376 | biostudies-literature
| S-EPMC397388 | biostudies-literature