Ontology highlight
ABSTRACT:
SUBMITTER: McCoy JM
PROVIDER: S-EPMC5418062 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
McCoy James M JM Stewart Rebecca J RJ Uboldi Alessandro D AD Li Dongdi D Schröder Jan J Scott Nicollas E NE Papenfuss Anthony T AT Lehane Adele M AM Foster Leonard J LJ Tonkin Christopher J CJ
The Journal of biological chemistry 20170303 18
<i>Toxoplasma gondii</i>, like all apicomplexan parasites, uses Ca<sup>2+</sup> signaling pathways to activate gliding motility to power tissue dissemination and host cell invasion and egress. A group of "plant-like" Ca<sup>2+</sup>-dependent protein kinases (CDPKs) transduces cytosolic Ca<sup>2+</sup> flux into enzymatic activity, but how they function is poorly understood. To investigate how Ca<sup>2+</sup> signaling activates egress through CDPKs, we performed a forward genetic screen to isol ...[more]