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Copper-catalyzed direct alkylation of heteroarenes.

ABSTRACT: An efficient and broadly applicable process is reported for the direct alkylation of C-H bonds in heteroarenes, privileged scaffolds in many areas of science. This reaction is based on the copper-catalyzed addition of alkyl radicals generated from activated secondary and tertiary alkyl bromides to a wide range of arenes, including furans, thiophenes, pyrroles, and their benzo-fused derivatives, as well as coumarins and quinolinones.

SUBMITTER: Theunissen C

PROVIDER: S-EPMC5418647 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Copper-catalyzed direct alkylation of heteroarenes.

Theunissen Cédric C Wang Jianjun J Evano Gwilherm G

Chemical science 20170320 5

An efficient and broadly applicable process is reported for the direct alkylation of C-H bonds in heteroarenes, privileged scaffolds in many areas of science. This reaction is based on the copper-catalyzed addition of alkyl radicals generated from activated secondary and tertiary alkyl bromides to a wide range of arenes, including furans, thiophenes, pyrroles, and their benzo-fused derivatives, as well as coumarins and quinolinones. ...[more]

PMID: 28507718

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