Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC5423537 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20170327 9
T cell factor 1 (Tcf1) is essential for T cell development; however, it remains controversial whether β-catenin, a known coactivator of Tcf1, has a role. Tcf1 is expressed in multiple isoforms in T lineage cells, with the long isoforms interacting with β-catenin through an N-terminal domain. In this study, we specifically ablated Tcf1 long isoforms in mice (p45<sup>-/-</sup>mice) to abrogate β-catenin interaction. Although thymic cellularity was diminished in p45<sup>-/-</sup> mice, transition o ...[more]