Ontology highlight
ABSTRACT:
SUBMITTER: Hydbring P
PROVIDER: S-EPMC5425285 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Hydbring Per P Wang Yinan Y Fassl Anne A Li Xiaoting X Matia Veronica V Otto Tobias T Choi Yoon Jong YJ Sweeney Katharine E KE Suski Jan M JM Yin Hao H Bogorad Roman L RL Goel Shom S Yuzugullu Haluk H Kauffman Kevin J KJ Yang Junghoon J Jin Chong C Li Yingxiang Y Floris Davide D Swanson Richard R Ng Kimmie K Sicinska Ewa E Anders Lars L Zhao Jean J JJ Polyak Kornelia K Anderson Daniel G DG Li Cheng C Sicinski Piotr P
Cancer cell 20170401 4
Cyclins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous human tumors. To identify means of interfering with cyclins/CDKs, we performed nine genome-wide screens for human microRNAs (miRNAs) directly regulating cell-cycle proteins. We uncovered a distinct class of miRNAs that target nearly all cyclins/CDKs, which are very effective in inhibiting cancer cell proliferation. By profiling the response of over 120 human cancer cell lines, we derived an expression-based algorithm that ...[more]