Ontology highlight
ABSTRACT:
SUBMITTER: Karimzadeh F
PROVIDER: S-EPMC5425659 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Stem cell reports 20170420 5
Calreticulin, a multifunctional endoplasmic reticulum resident protein, is required for TGF-β-induced epithelial-to-mesenchymal transition (EMT) and subsequent cardiomyogenesis. Using embryoid bodies (EBs) derived from calreticulin-null and wild-type (WT) embryonic stem cells (ESCs), we show that expression of EMT and cardiac differentiation markers is induced during differentiation of WT EBs. This induction is inhibited in the absence of calreticulin and can be mimicked by inhibiting TGF-β sign ...[more]