Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Guerrero AM
PROVIDER: S-EPMC5428229 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lopez-Guerrero Aida M AM Tomas-Martin Patricia P Pascual-Caro Carlos C Macartney Thomas T Rojas-Fernandez Alejandro A Ball Graeme G Alessi Dario R DR Pozo-Guisado Eulalia E Martin-Romero Francisco Javier FJ
Scientific reports 20170324 1
Cell motility and migration requires the reorganization of the cortical cytoskeleton at the leading edge of cells and extracellular Ca<sup>2+</sup> entry is essential for this reorganization. However the molecular nature of the regulators of this pathway is unknown. This work contributes to understanding the role of STIM1 and ORAI1 in the promotion of membrane ruffling by showing that phospho-STIM1 localizes at the leading edge of cells, and that both phospho-STIM1 and ORAI1 co-localize with cor ...[more]