Ontology highlight
ABSTRACT:
SUBMITTER: Saintamand A
PROVIDER: S-EPMC5428668 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20170327 1
Enhancer and super-enhancers are master regulators of cell fate. While they act at long-distances on adjacent genes, it is unclear whether they also act on one another. The immunoglobulin heavy chain (IgH) locus is unique in carrying two super-enhancers at both ends of the constant gene cluster: the 5'E<sub>μ</sub> super-enhancer promotes VDJ recombination during the earliest steps of B-cell ontogeny while the 3' regulatory region (3'RR) is essential for late differentiation. Since they carry fu ...[more]