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Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach.

ABSTRACT: Acute myeloid leukemia (AML) is an aggressive malignancy with only a handful of therapeutic options. About 30% of AML patients harbor mutated FLT3 kinase, and thus, this cancer-driver has become a hotly pursued AML target. Herein we report a new class of FLT3 inhibitors, which potently inhibit the proliferation of acute myeloid leukemia (AML) cells at nanomolar concentrations.

SUBMITTER: Ma X

PROVIDER: S-EPMC5430396 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach.

Ma Xiaochu X Zhou Jie J Wang Changhao C Carter-Cooper Brandon B Yang Fan F Larocque Elizabeth E Fine Jonathan J Tsuji Genichiro G Chopra Gaurav G Lapidus Rena G RG Sintim Herman O HO

ACS medicinal chemistry letters 20170414 5

Acute myeloid leukemia (AML) is an aggressive malignancy with only a handful of therapeutic options. About 30% of AML patients harbor mutated FLT3 kinase, and thus, this cancer-driver has become a hotly pursued AML target. Herein we report a new class of FLT3 inhibitors, which potently inhibit the proliferation of acute myeloid leukemia (AML) cells at nanomolar concentrations. ...[more]

PMID: 28523099

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Project description: Not available

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