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Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs).

ABSTRACT: The potential environmental impact of nanomaterials is a critical concern and the ability to assess these potential impacts is top priority for the progress of sustainable nanotechnology. Risk assessment tools are needed to enable decision makers to rapidly assess the potential risks that may be imposed by engineered nanomaterials (ENMs), particularly when confronted by the reality of limited hazard or exposure data. In this review, we examine a range of available risk assessment frameworks considering the contexts in which different stakeholders may need to assess the potential environmental impacts of ENMs. Assessment frameworks and tools that are suitable for the different decision analysis scenarios are then identified. In addition, we identify the gaps that currently exist between the needs of decision makers, for a range of decision scenarios, and the abilities of present frameworks and tools to meet those needs.

SUBMITTER: Romero-Franco M

PROVIDER: S-EPMC5433198 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs).

Romero-Franco Michelle M Godwin Hilary A HA Bilal Muhammad M Cohen Yoram Y

Beilstein journal of nanotechnology 20170505

The potential environmental impact of nanomaterials is a critical concern and the ability to assess these potential impacts is top priority for the progress of sustainable nanotechnology. Risk assessment tools are needed to enable decision makers to rapidly assess the potential risks that may be imposed by engineered nanomaterials (ENMs), particularly when confronted by the reality of limited hazard or exposure data. In this review, we examine a range of available risk assessment frameworks cons ...[more]

PMID: 28546894

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Project description:BackgroundEngineered nanomaterials (ENM) are used extensively in food products to fulfill a number of roles, including enhancement of color and texture, for nutritional fortification, enhanced bioavailability, improved barrier properties of packaging, and enhanced food preservation. Safety assessment of ingested engineered nanomaterials (iENM) has gained interest in the nanotoxicology community in recent years. A variety of test systems and approaches have been used for such evaluations, with in vitro monoculture cell models being the most common test systems, owing to their low cost and ease-of-use. The goal of this review is to systematically assess the current state of science in toxicological testing of iENM, with particular emphasis on model test systems, their physiological relevance, methodological strengths and challenges, realistic doses (ranges and rates), and then to identify future research needs and priorities based on these assessments.MethodsExtensive searches were conducted in Google Scholar, PubMed and Web of Science to identify peer-reviewed literature on safety assessment of iENM over the last decade, using keywords such as "nanoparticle", "food", "toxicity", and combinations thereof. Relevant literature was assessed based on a set of criteria that included the relevance of nanomaterials tested; ENM physicochemical and morphological characterization; dispersion and dosimetry in an in vitro system; dose ranges employed, the rationale and dose realism; dissolution behavior of iENM; endpoints tested, and the main findings of each study. Observations were entered into an excel spreadsheet, transferred to Origin, from where summary statistics were calculated to assess patterns, trends, and research gaps.ResultsA total of 650 peer-reviewed publications were identified from 2007 to 2017, of which 39 were deemed relevant. Only 21% of the studies used food grade nanomaterials for testing; adequate physicochemical and morphological characterization was performed in 53% of the studies. All in vitro studies lacked dosimetry and 60% of them did not provide a rationale for the doses tested and their relevance. Only 12% of the studies attempted to consider the dissolution kinetics of nanomaterials. Moreover, only 1 study attempted to prepare and characterize standardized nanoparticle dispersions.ConclusionWe identified 5 clusters of factors deemed relevant to nanotoxicology of food-grade iENM: (i) using food-grade nanomaterials for toxicity testing; (ii) performing comprehensive physicochemical and morphological characterization of iENM in the dry state, (iii) establishing standard NP dispersions and their characterization in cell culture medium, (iv) employing realistic dose ranges and standardized in vitro dosimetry models, and (v) investigating dissolution kinetics and biotransformation behavior of iENM in synthetic media representative of the gastrointestinal (GI) tract fluids, including analyses in a fasted state and in the presence of a food matrix. We discussed how these factors, when not considered thoughtfully, could influence the results and generalizability of in vitro and in vivo testing. We conclude with a set of recommendations to guide future iENM toxicity studies and to develop/adopt more relevant in vitro model systems representative of in vivo animal and human iENM exposure scenarios.

Project description:Sustainable Consumption and Production is one of the leading principle towards reducing environmental impacts globally. This study aims at combining Environmentally-Extended Input-Output Analysis (using EXIOBASE 3) with up-to-date impact assessment models to quantify the environmental impacts induced by final consumption in the EU Member States in 2011. The environmental extensions are characterized in 14 environmental impact categories out of the 16 used in the Environmental Footprint life cycle impact assessment method. A contribution analysis of key products and services as well as emissions and resources, which drive the environmental impacts of EU consumption, is conducted. Environmental impacts are mainly induced along the supply-chain of products and services. Several expenditures relative to services represent large shares both in the total final consumption and in the 14 impacts under study, despite a relatively low impact intensity. Food products, in particular meat and dairy products, are identified as key contributors regarding acidification, eutrophication, land use, and water use, and to a lower extent climate change. Finally, several manufactured products, raw materials and basic products respectively importantly contribute to impacts on human toxicity, freshwater ecotoxicity and resource uses. The total volume of final consumption expenditures per EU Member State appears a key explanatory variable to most of the impacts embodied in their consumption, yet to a lower extent regarding water use and fossils resource use. Finally, the current limitations in using EXIOBASE 3 for environmental impact assessment are discussed, with specific attention to EXIOBASE environmental extensions and to the case study on EU consumption. Since the classification of emissions and resources for impact assessment requires a number of assumptions that may influence the results, a sensitivity analysis is performed to exemplify some of the key issues relative to the characterization of impacts based on EXIOBASE environmental extensions.

Dataset Information

Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs).

Publications

Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs).

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