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Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo.

ABSTRACT: Extended-release gastrointestinal (GI) luminal delivery substantially increases the ease of administration of drugs and consequently the adherence to therapeutic regimens. However, because of clearance by intrinsic GI motility, device gastroretention and extended drug release over a prolonged duration are very challenging. Here, we report that GI parasite-inspired active mechanochemical therapeutic grippers, or theragrippers, can reside within the GI tract of live animals for 24 hours by autonomously latching onto the mucosal tissue. We also observe a notable sixfold increase in the elimination half-life using theragripper-mediated delivery of a model analgesic ketorolac tromethamine. These results provide first-in-class evidence that shape-changing and self-latching microdevices enhance the efficacy of extended drug delivery.

SUBMITTER: Ghosh A

PROVIDER: S-EPMC7608789 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo.

Ghosh Arijit A Li Ling L Xu Liyi L Dash Ranjeet P RP Gupta Neha N Lam Jenny J Jin Qianru Q Akshintala Venkata V Pahapale Gayatri G Liu Wangqu W Sarkar Anjishnu A Rais Rana R Gracias David H DH Selaru Florin M FM

Science advances 20201028 44

Extended-release gastrointestinal (GI) luminal delivery substantially increases the ease of administration of drugs and consequently the adherence to therapeutic regimens. However, because of clearance by intrinsic GI motility, device gastroretention and extended drug release over a prolonged duration are very challenging. Here, we report that GI parasite-inspired active mechanochemical therapeutic grippers, or theragrippers, can reside within the GI tract of live animals for 24 hours by autonom ...[more]

PMID: 33115736

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