Ontology highlight
ABSTRACT:
SUBMITTER: Parks T
PROVIDER: S-EPMC5437274 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Parks Tom T Mirabel Mariana M MM Kado Joseph J Auckland Kathryn K Nowak Jaroslaw J Rautanen Anna A Mentzer Alexander J AJ Marijon Eloi E Jouven Xavier X Perman Mai Ling ML Cua Tuliana T Kauwe John K JK Allen John B JB Taylor Henry H Robson Kathryn J KJ Deane Charlotte M CM Steer Andrew C AC Hill Adrian V S AVS
Nature communications 20170511
The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying by ancestry, we analysed genotyped and imputed variants in Melanesians (607 cases and 1,229 controls) before follow-up of suggestive loci in three further ancestral groups: Polynesians, South Asians and Mixed or other populations (totalling 399 ...[more]