Ontology highlight
ABSTRACT:
SUBMITTER: Bartolome-Izquierdo N
PROVIDER: S-EPMC5437734 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Blood 20170210 17
Non-Hodgkin lymphoma comprises a variety of neoplasms, many of which arise from germinal center (GC)-experienced B cells. microRNA-28 (miR-28) is a GC-specific miRNA whose expression is lost in numerous mature B-cell neoplasms. Here we show that miR-28 regulates the GC reaction in primary B cells by impairing class switch recombination and memory B and plasma cell differentiation. Deep quantitative proteomics combined with transcriptome analysis identified miR-28 targets involved in cell-cycle a ...[more]