Ontology highlight
ABSTRACT:
SUBMITTER: Li SS
PROVIDER: S-EPMC5442120 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Li Shan-Shan SS Guan Qi-Yuan QY Meng Gang G Chang Xiao-Feng XF Wei Ji-Wu JW Wang Peng P Kang Bin B Xu Jing-Juan JJ Chen Hong-Yuan HY
Scientific reports 20170523 1
Better understanding the drug action within cells may extend our knowledge on drug action mechanisms and promote new drugs discovery. Herein, we studied the processes of drug induced chemical changes on proteins and nucleic acids in human breast adenocarcinoma (MCF-7) cells via time-resolved plasmonic-enhanced Raman spectroscopy (PERS) in combination with principal component analysis (PCA). Using three popular chemotherapy drugs (fluorouracil, cisplatin and camptothecin) as models, chemical chan ...[more]