Ontology highlight
ABSTRACT:
SUBMITTER: Brasacchio D
PROVIDER: S-EPMC5442465 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Brasacchio Daniella D Alsop Amber E AE Noori Tahereh T Lufti Mariam M Iyer Sweta S Simpson Kaylene J KJ Bird Phillip I PI Kluck Ruth M RM Johnstone Ricky W RW Trapani Joseph A JA
Cell death and differentiation 20170106 6
PCAF and ADA3 associate within the same macromolecular complexes to control the transcription of many genes, including some that regulate apoptosis. Here we show that PCAF and ADA3 regulate the expression of PACS1, whose protein product is a key component of the machinery that sorts proteins among the trans-Golgi network and the endosomal compartment. We describe a novel role for PACS1 as a regulator of the intrinsic pathway of apoptosis and mitochondrial outer membrane permeabilization. Cells w ...[more]