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Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions.

ABSTRACT: Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild conditions allow a broad functional group tolerance.

SUBMITTER: Tona V

PROVIDER: S-EPMC5442602 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions.

Tona Veronica V Maryasin Boris B de la Torre Aurélien A Sprachmann Josefine J González Leticia L Maulide Nuno N

Organic letters 20170509 10

Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild conditions allow a broad functional group tolerance. ...[more]

PMID: 28485608

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