Ontology highlight
ABSTRACT:
SUBMITTER: Garg R
PROVIDER: S-EPMC5444089 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Garg Rachana R Blando Jorge M JM Perez Carlos J CJ Abba Martin C MC Benavides Fernando F Kazanietz Marcelo G MG
Cell reports 20170401 2
PKCε, an oncogenic member of the PKC family, is aberrantly overexpressed in epithelial cancers. To date, little is known about functional interactions of PKCε with other genetic alterations, as well as the effectors contributing to its tumorigenic and metastatic phenotype. Here, we demonstrate that PKCε cooperates with the loss of the tumor suppressor Pten for the development of prostate cancer in a mouse model. Mechanistic analysis revealed that PKCε overexpression and Pten loss individually an ...[more]