Ontology highlight
ABSTRACT:
SUBMITTER: Sato Y
PROVIDER: S-EPMC5448099 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Sato Yoshifumi Y Tsuyama Tomonori T Sato Chinami C Karim Md Fazlul MF Yoshizawa Tatsuya T Inoue Masahiro M Yamagata Kazuya K
The Journal of biological chemistry 20170331 21
Hypoxia plays a role in the deterioration of β-cell function. Hepatocyte nuclear factor 4α (HNF4α) has an important role in pancreatic β-cells, and mutations of the human <i>HNF4A</i> gene cause a type of maturity-onset diabetes of the young (MODY1). However, it remains unclear whether hypoxia affects the expression of HNF4α in β-cells. Here, we report that hypoxia reduces HNF4α protein expression in β-cells. Hypoxia-inducible factor was not involved in the down-regulation of HNF4α under hypoxic ...[more]