Ontology highlight
ABSTRACT:
SUBMITTER: Funk P
PROVIDER: S-EPMC5448738 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
PloS one 20170530 5
2-Aminoquinolin-4(1H)-one was reacted with various primary/secondary amines and paraformaldehyde under Mannich reaction conditions. In the case of secondary amines, the reaction in N,N-dimethylformamide yielded expected Mannich products accompanied with 3,3'-methylenebis(2-aminoquinolin-4(1H)-one). Except these main products, the pyrimido[4,5-b]quinolin-5-one derivative was also identified as co-product. The reaction with primary amines led to the formation of pyrimido[4,5-b]quinolin-5-ones. The ...[more]