Ontology highlight
ABSTRACT:
SUBMITTER: Brose L
PROVIDER: S-EPMC5449144 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Brose Lotti L Crest Justin J Tao Li L Sullivan William W
Molecular biology of the cell 20170405 11
Animal cytokinesis involves both actin-myosin-based contraction and vesicle-mediated membrane addition. In many cell types, including early <i>Drosophila</i> embryos, Nuf/FIP3, a Rab11 effector, mediates recycling endosome (RE)-based vesicle delivery to the cytokinesis furrow. Nuf exhibits a cell cycle-regulated concentration at the centrosome that is accompanied by dramatic changes in its phosphorylation state. Here we demonstrate that maximal phosphorylation of Nuf occurs at prophase, when cen ...[more]