IFN-?, IL-2, IP-10, and MIG as Biomarkers of Exposure to Leishmania spp., and of Cure in Human Visceral Leishmaniasis.

ABSTRACT: New biomarkers are needed for monitoring the effectiveness of treatment for visceral leishmaniasis (VL). They might also improve the detection of the asymptomatic population in Leishmania-endemic areas. This paper examines the IL-2, IFN-?, IFN-?-induced protein 10 (IP-10), and monokine-induced-by-IFN-? (MIG) levels in whole blood-stimulated in vitro with soluble Leishmania antigen (SLA)-taken from asymptomatic individuals and patients treated for VL living in a post-outbreak (Leishmania infantum) area in Spain, and in an endemic (Leishmania donovani) area of Bangladesh. IP-10 was found to be an accurate global marker of asymptomatic subjects with positive cellular/humoral tests, while MIG was found to be a better marker of contact with L. donovani than IL-2 but no for those with L. infantum. Determining IP-10, MIG, and IFN-? levels proved useful in monitoring the cellular immune response following treatment for active disease caused by L. infantum.

SUBMITTER: Ibarra-Meneses AV 

PROVIDER: S-EPMC5449718 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature