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Ferrocenyl chiral bisphosphorus ligands for highly enantioselective asymmetric hydrogenation via noncovalent ion pair interaction.


ABSTRACT: A new class of ferrocenyl chiral bisphosphorus ligand, Wudaphos, was developed, and exhibits excellent ee and activity (ee up to 99%, TON up to 20?000) for the asymmetric hydrogenation of both 2-aryl and 2-alkyl acrylic acids through ion pair noncovalent interaction under base free and mild reaction conditions. Well-known anti-inflammatory drugs such as naproxen and ibuprofen together with the intermediate for the preparation of Roche ester and some bioactive compounds were also efficiently obtained with excellent ee. Control experiments were conducted and revealed that the ion pair noncovalent interaction and chain length played important roles.

SUBMITTER: Chen C 

PROVIDER: S-EPMC5450526 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Ferrocenyl chiral bisphosphorus ligands for highly enantioselective asymmetric hydrogenation <i>via</i> noncovalent ion pair interaction.

Chen Caiyou C   Wang Heng H   Zhang Zhefan Z   Jin Shicheng S   Wen Songwei S   Ji Jianjian J   Chung Lung Wa LW   Dong Xiu-Qin XQ   Zhang Xumu X  

Chemical science 20160630 11


A new class of ferrocenyl chiral bisphosphorus ligand, Wudaphos, was developed, and exhibits excellent <i>ee</i> and activity (<i>ee</i> up to 99%, TON up to 20 000) for the asymmetric hydrogenation of both 2-aryl and 2-alkyl acrylic acids through ion pair noncovalent interaction under base free and mild reaction conditions. Well-known anti-inflammatory drugs such as naproxen and ibuprofen together with the intermediate for the preparation of Roche ester and some bioactive compounds were also ef  ...[more]

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