Unknown

Dataset Information

0

Chiral ion-pair organocatalyst promotes highly enantioselective 3-exo iodo-cycloetherification of allyl alcohols.


ABSTRACT: By designing a novel chiral ion-pair organocatalyst composed of chiral phosphate and DABCO-derived quaternary ammonium, highly enantioselective 3-exo iodo-cycloetherification of allyl alcohols was achieved using NIS as a halogen source. Based on this reaction, one-pot asymmetric 3-exo iodo-cycloetherification/Wagner-Meerwein rearrangement of allyl alcohols en route to enantioenriched 2-iodomethyl-2-aryl cycloalkanones was subsequently developed. Due to the participation of adjacent iodine, the Wagner-Meerwein rearrangement of 2-iodomethyl-2-aryl epoxide proceeds with unusual retention of stereoconfiguration.

SUBMITTER: Shen Z 

PROVIDER: S-EPMC5947518 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Chiral ion-pair organocatalyst promotes highly enantioselective 3-<i>exo</i> iodo-cycloetherification of allyl alcohols.

Shen Zhigao Z   Pan Xixian X   Lai Yisheng Y   Hu Jiadong J   Wan Xiaolong X   Li Xiaoge X   Zhang Hui H   Xie Weiqing W  

Chemical science 20150827 12


By designing a novel chiral ion-pair organocatalyst composed of chiral phosphate and DABCO-derived quaternary ammonium, highly enantioselective 3-<i>exo</i> iodo-cycloetherification of allyl alcohols was achieved using NIS as a halogen source. Based on this reaction, one-pot asymmetric 3-<i>exo</i> iodo-cycloetherification/Wagner-Meerwein rearrangement of allyl alcohols en route to enantioenriched 2-iodomethyl-2-aryl cycloalkanones was subsequently developed. Due to the participation of adjacent  ...[more]

Similar Datasets

| S-EPMC7898328 | biostudies-literature
| S-EPMC5450526 | biostudies-literature
| S-EPMC2995725 | biostudies-literature
| S-EPMC4807613 | biostudies-literature
| S-EPMC5121337 | biostudies-literature
| S-EPMC8119980 | biostudies-literature
| S-EPMC2536621 | biostudies-literature
| S-EPMC2925184 | biostudies-literature
| S-EPMC6270052 | biostudies-literature
| S-EPMC6120892 | biostudies-other