Ontology highlight
ABSTRACT:
SUBMITTER: Jomaa A
PROVIDER: S-EPMC5454536 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Jomaa Ahmad A Jomaa Ahmad A Fu Yu-Hsien Hwang YH Boehringer Daniel D Leibundgut Marc M Shan Shu-Ou SO Ban Nenad N
Nature communications 20170519
During co-translational protein targeting, the signal recognition particle (SRP) binds to the translating ribosome displaying the signal sequence to deliver it to the SRP receptor (SR) on the membrane, where the signal peptide is transferred to the translocon. Using electron cryo-microscopy, we have determined the structure of a quaternary complex of the translating Escherichia coli ribosome, the SRP-SR in the 'activated' state and the translocon. Our structure, supported by biochemical experime ...[more]