Ontology highlight
ABSTRACT:
SUBMITTER: Rowlett JK
PROVIDER: S-EPMC545524 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Rowlett James K JK Platt Donna M DM Lelas Snjezana S Atack John R JR Dawson Gerard R GR
Proceedings of the National Academy of Sciences of the United States of America 20050111 3
Benzodiazepines exert their effects by binding to multiple subtypes of the GABAA receptor, the predominant subtypes in the brain being those that contain alpha1-, alpha2-, alpha3-, and alpha5-subunits. To understand the potentially different roles of these subtypes in the therapeutic and side effects of benzodiazepines, we evaluated GABAA receptor subtype-preferring compounds in nonhuman primate models predictive of anxiolytic, sedative, motor, subjective, and reinforcing effects of benzodiazepi ...[more]