Ontology highlight
ABSTRACT:
SUBMITTER: Jayatilaka H
PROVIDER: S-EPMC5458548 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nature communications 20170526
Following uncontrolled proliferation, a subset of primary tumour cells acquires additional traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized to be the initiators of metastasis. This study reveals an adaptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, which is amplified by cell proliferation and cell density, to directly promote cell migration. This effect occurs in metastatic human sarcoma and carcinoma cells- but not in normal ...[more]