Ontology highlight
ABSTRACT:
SUBMITTER: Levin-Klein R
PROVIDER: S-EPMC5459994 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nature communications 20170530
Although much has been done to understand how rearrangement of the Igκ locus is regulated during B-cell development, little is known about the way the variable (V) segments themselves are selected. Here we show, using B6/Cast hybrid pre-B-cell clones, that a limited number of V segments on each allele is stochastically activated as characterized by the appearance of non-coding RNA and histone modifications. The activation states are clonally distinct, stable across cell division and developmenta ...[more]