Ontology highlight
ABSTRACT:
SUBMITTER: Park SK
PROVIDER: S-EPMC5460882 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Park Sei-Kyoung SK Hong Joo Y JY Arslan Fatih F Kanneganti Vydehi V Patel Basant B Tietsort Alex A Tank Elizabeth M H EMH Li Xingli X Barmada Sami J SJ Liebman Susan W SW
PLoS genetics 20170522 5
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons with inclusions frequently containing the RNA/DNA binding protein TDP-43. Using a yeast model of ALS exhibiting TDP-43 dependent toxicity, we now show that TDP-43 overexpression dramatically alters cell shape and reduces ubiquitin dependent proteolysis of a reporter construct. Furthermore, we show that an excess of the Hsp40 chaperone, Sis1, reduced TDP-43's effect on t ...[more]