Dataset Information

Sources of heterogeneity in studies of the BMI-mortality association.

ABSTRACT:

Background

To date, the amount of heterogeneity among studies of the body mass index-mortality association attributable to differences in the age distribution and length of follow-up has not been quantified. Therefore, we wanted to quantify the amount of heterogeneity attributable to age and follow-up in results of studies on the body mass index-mortality relation.

Methods

We used optima of the body mass index mortality association reported for 30 populations and performed meta-regression to estimate the amount of heterogeneity attributable to sex, ethnicity, mean age at baseline, percentage smokers, and length of follow-up.

Results

Ethnicity as single factor accounted for 36% (95% CI, 11-56%) of heterogeneity. Mean age and length of follow-up had an interactive effect and together accounted for 56% (95% CI, 24-74%) of the remaining heterogeneity. Sex did not significantly contribute to the heterogeneity, after controlling for ethnicity, age, and length of follow-up.

Conclusions

A considerable amount of heterogeneity in studies of the body mass index-mortality association is attributable to ethnicity, age, and length of follow-up.

SUBMITTER: Peter RS

PROVIDER: S-EPMC5463020 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Sources of heterogeneity in studies of the BMI-mortality association.

Peter Raphael Simon RS Nagel Gabriele G

Journal of epidemiology 20170228 6

<h4>Background</h4>To date, the amount of heterogeneity among studies of the body mass index-mortality association attributable to differences in the age distribution and length of follow-up has not been quantified. Therefore, we wanted to quantify the amount of heterogeneity attributable to age and follow-up in results of studies on the body mass index-mortality relation.<h4>Methods</h4>We used optima of the body mass index mortality association reported for 30 populations and performed meta-re ...[more]

PMID: 28256294

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Dataset Information

Sources of heterogeneity in studies of the BMI-mortality association.

Background

Methods

Results

Conclusions

Publications

Sources of heterogeneity in studies of the BMI-mortality association.

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