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Facile synthesis of chlorin bioconjugates by a series of click reactions.

ABSTRACT: A multifunctional chlorin platform appended with four short polyethylene glycols and a carboxylate-linker allows rapid conjugation to biotargeting motifs such as proteins and oligonucleotides. The stability and photophysical properties of the chlorin enable development of diagnostics, imaging, molecular tracking, and theranostics.

SUBMITTER: Gonzales J

PROVIDER: S-EPMC5463999 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Facile synthesis of chlorin bioconjugates by a series of click reactions.

Gonzales Junior J Bhupathiraju N V S Dinesh K NV Perea William W Chu Huong H Berisha Naxhije N Bueno Veronica V Dodic Naser N Rozenberg Julia J Greenbaum Nancy L NL Drain Charles Michael CM

Chemical communications (Cambridge, England) 20170301 26

A multifunctional chlorin platform appended with four short polyethylene glycols and a carboxylate-linker allows rapid conjugation to biotargeting motifs such as proteins and oligonucleotides. The stability and photophysical properties of the chlorin enable development of diagnostics, imaging, molecular tracking, and theranostics. ...[more]

PMID: 28304032

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